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KMID : 1007020120100030119
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Korean Soceity of Osteroporosis
2012 Volume.10 No. 3 p.119 ~ p.128
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The Association between Single Nucleotide Polymorphisms of Sclerostin (SOST) Gene, Bone Mineral Density and Circulating Osteoprotegerin (OPG) ?Soluble Receptor Activator of NF-κB Ligand (sRANKL) in Postmenopausal Korean Women
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Lee Hee-Jun
Kim Hoon
Ku Seung-Yup
Kim Seok-Hyun
Choi Young-Min
Kim Jung-Gu
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Abstract
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Objectives: To investigate the relationship between polymorphisms of sclerostin (SOST) gene and bone mineral density (BMD) in postmenopausal Korean women. Materials and Methods: The SOST rs865429 (g.5942C>T), rs17882143 (c.28G>A), rs10534024 (-1396TCC/Del) polymorphisms were analyzed by Taqman assay and direct DNA sequencing in 399 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin, osteoprotegerin (OPG) and soluble receptor activator of NF-kB ligand (sRANKL) were measured by enzyme linked immunosorbent assay. The BMD at the lumbar spine (LS) and femoral neck (FN) were determined by dual energy X-ray absorptiometry, and in 311 postmenopausal women receiving hormone therapy (HT) BMD was also measured after HT of 1 year. Results: The SOST g.5942C>T and c.28G>A polymorphisms were not observed. No significant differences in adjusted BMD at LS and FN, prevalence for osteoporosis and serum levels of biochemical markers were noted among genotypes of the SOST -1396TCC/del polymorphism. A significant association was found between SOST -1396TCC/Del polymorphism and the annual percent changes of BMD at LS but not FN after HT. The Del/Del genotype showed a significant decrease in BMD after HT compared with other genotypes. Conclusions: The SOST -1396TCC/Del polymorphism affects an annual BMD change at LS after HT in postmenopausal Korean women.
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KEYWORD
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BMD, Genetic polymorphism, Hormone therapy, SOST
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